If you’ve ever wondered what sertralina is, you’re not alone. However, if you are taking Sertraline for a condition like obsessive-compulsive disorder, you should know that it’s not suitable for you.
Sertraline is a serotonin transporter inhibitor
As a serotonin transporter inhibitor, sertraline has a unique structure that binds to the protein. The molecule is rigid and maintains a low energy configuration upon binding to its target protein. Its ligand-binding activity is dependent on the affinity of the molecule for the transporter. Therefore, ligand-binding affinities must be high to inhibit the transport of serotonin in the brain.
The serotonin transporter carries serotonin molecules across the membrane by undergoing conformational changes and moving one or more molecules per cycle. In contrast to channels, which remain open and closed to allow floods of molecules to pass, the SERT carries serotonin molecules in a cycle. Molecular structures of serotonin transporters resemble those of many other biogenic amine transporters.
It is metabolized by multiple cytochrome P450 enzymes
As a prescription medicine, Sertralina is metabolized by several cytochrome P450 enzymes. These enzymes determine the concentration of the parent drug and metabolites. These compounds may not be pharmacologically active. Metabolites may also have different properties than the parent drug. For example, nefazodone is a well-known antidepressant. Its active metabolite, meta-chlorophenylpiperazine (mCPP), is an anxiogenic.
In the 1960s, Remmer and associates showed that barbiturates could accelerate drug clearance. Other research by James and Elizabeth Miller and Allan Conney demonstrated that xenobiotic chemicals induce drug metabolism. These developments led pharmaceutical scientists to better appreciate the role of drug metabolism. However, until recently, the majority of drug metabolism research involved preclinical animal models. In the 1960s, however, basic in vitro research was possible.
It can cause serotonin syndrome
Although sertralina can cause serotonin syndrome, it can also lead to other side effects. The FDA has prompted drugmakers to add a warning label about the potential for serotonin syndrome. In some cases, this condition can be severe enough to cause seizures, breathing problems, and coma.
Other drugs that can increase your risk of serotonin syndrome include monoamine oxidase inhibitors. You must wait at least 14 days after taking an MAO inhibitor to start taking sertraline. Nonsteroidal anti-inflammatory drugs, lithium, and intravenous methylene blue may also increase your risk of serotonin syndrome. If you’re taking any of these drugs, you should consult a doctor as soon as possible to rule out any interactions.
It is not recommended for patients with trastorno obsessivo-compulsivo
There are several pharmacological treatments available for obsessional-compulsive disorder. The most commonly used is selective serotonin reuptake inhibitors (SSRIs).
Patients should also inform their doctor if they become. pregnant while taking sertraline, as it can harm the developing baby. Sertraline should be avoided during pregnancy. and during breastfeeding, because it can cause birth defects.
It is a dopamine transporter inhibitor
Dopamine reuptake inhibitors (DARIs) inhibit the transport of extracellular dopamine by blocking the cellmembrane-standing dopamine transporter. These drugs block the transporter’s ability to take in dopamine, while allowing small molecules such as dopamine to pass through. They also suppress the binding of other substances to the transporter. Drugs like Sertralina are substrates for these transporters.
In the present study, Sertraline inhibited action potentials of VD4 neuronal subtypes. It inhibited the pre-synaptic cell VD4 and clamped the action potential of the neuron during an induced burst. This study also found that Sertraline inhibits the action potential of hippocampal nerve endings. Its effects on the transporter may be reversible.